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Scientists 'uncover potential drug candidates for cystic fibrosis'

Tuesday 1st November 2011
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Scientists have discovered a potential new drug candidates for cystic fibrosis and other diseases, according to new research.

A study published in the FASEB Journal explained how researchers used high-throughput screening to detect small-molecule drug candidates which help cells to bypass defective channels that usually move salt and water through cell membranes.

The drug candidates activate an alternative chloride channel called TMEM16A that could be effective in treating certain conditions, including cystic fibrosis, dry eye and dry mouth diseases, and slow-transit constipation.

Authors believe that further pre-clinical development of the chloride channel activators identified in the study could lead to new therapies for these conditions.

"Scientists have known for decades that cells have more than one way to move salt and water. Indeed, over the years many useful drugs have been developed that influence these movements in the heart and kidneys," said Gerald Weissman, editor-in-chief of the journal.

Posted by Alex Franklin StortfordADNFCR-1780-ID-800783517-ADNFCR

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